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NCL-Correlated Proteins:
Geneloci - Isoforms - Expression-data.01
Processes and mechanisms leading to synthesis of a cellspecific messenger-RNA I have described in detail in “Die formatierte DNA”. According to this work the basis of any coordinated activation of genes is set up by the formatting of distinct chromatin domains in phase with a homogenous spacing. Only genes being located in domains, which are formatted with same spacing, can be regulated in common and activated in a coordinated and synchronized manner. (To get more information about this revolutionary, convincing global theory of gene expression in humans look here.)
Preliminary remarks related to the following tables:
Defining a distinct number of isoforms for a protein does not mean this number being identic with the number of transcripts being generated for the specific protein. For MTTDC (16 isoforms postulated) by example likely exist around 50 different transcripts, which will be expressed during different periods of ontogenesis in different cells. With other words: a protein consisting of a distinct polypeptidchain may have been generated from two or more different transcripts, them only differring in the length of the 5’ and/or 3’ noncoding areas. Vice versa this also means, that the number of transcripts must not be identic with the number of different proteins, encoded by the specific gene.
The expression periods defined below for distinct isoforms of a protein therefore only show the timeframe, within which a specific isoform will be generated in various cells at varying times. Related to a specific cell or group of cells the actual time of expression within this timeframe therefore may be shorter or longer. That is to say: a distinct transcript sometimes may be generated at different times in also different cells. To show all these relations in the scope of this work is not possible, even though I would be able to show expression times for any specific isoform and cell.
The term “oligodendroglia” mentioned in the following tables refers to a group of specialised cells, which resemble each other - even they are according to my evaluations descended from a common stem cell - not very much in their form and appearance and still less in relation to their function. One of these cells is the oligodendrocyte, which is building the myelin sheath of the neuronal axon in the central nervous system of higher vertebrates (brain and spinal cord) - a function, which is performed by Schwann cells in the peripheral nervous system.
The other one is not very well evaluated and its function is in large parts unclear. The so called “satellite oligodendrocytes” - sometimes also named astrocytes - are always found in the neighbourhood of neurons, to which they have a lot of contacts via their cellular branches. I postulate satellite oligodendrocytes to have a function similar to nurse cells - they help regulate the content of natrium and calcium ions of their linked neurons, supply them with glykogen in case of high consumption and may also deliver neurotransmitters like glutamate or acetylcholin if needed. They in this way form a kind of emergency troop, helping neurons to keep up their function and to survive in critical or stressing periods with lacking resources.
The tables are sorted by begin of expression of the distinct isoform.
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Protein: multivalent terpene and terpenoid decyclase
16 postulated isoforms in total, all being encoded by the NCL-gene-network.
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Inducing Formatting-
Hormone
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Protein or pre-
cursor(s) coded on gene(s)
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supposed to be expressed during ontogenesis in one or more of the following celltypes or varying combinations of these cells
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Supposed to be expressed from-to (ca.)
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HPL
Isoform 1
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CLN3
DHRS7
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(progenitors of) astroglia, oligodendroglia, microglia, Schwann-cells, lymphocytes, muscle cells smooth and striated and others.
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day 60 till
day 160
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HPL
Isoform 2
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DHRS7
USP10
CES7
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as before
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day 160 till
day 200
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PROG
Isoform 3
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CLN3 (339aa)
ENSP00000350457
CES7
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astroglia, oligodendroglia, microglia, Schwann-cells, lymphocytes, muscle cells smooth and striated and others.
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day 200
till birth
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MSH-RH
Isoform 4
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CLN3
CLN6
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as before
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from day 200 till end of life
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THYM-b10
Isoform 5
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NOMO2
DHRS7
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as before
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from birth till end of y5
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TRH
Isoform 6
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CLN3 (253aa)
ENSP00000349586
NOMO2
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as before
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from birth till begin of puberty
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GH-RH
Isoform 7
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CES7
NOMO2
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as before
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from birth till begin of puberty
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PROG
Isoform 8
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CLN3
GPC6
CES7
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as before
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from birth till end of puberty
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CRH
Isoform 9
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CLN3
CLN8
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see diagram for gene CLN8
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from birth till end of puberty
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GH-RH
Isoform 10
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CLN3 (438aa)
ENSP00000353073
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as before
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from birth till adult (~y21)
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GH-RH
Isoform 11
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CLN3 (421aa)
ENSP00000346650
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as before
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from birth till adult (~y21)
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MSH-RH
Isoform 12
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CLN3 (438aa)
ENSP00000350523
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as before
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from birth
till adult (~y21)
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GH-RH
Isoform 13
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CLN3
NOMO2
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as before
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from end of y5 till ~year 35
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Gn-RH
Isoform 14
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USP10
SERPINB11
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as before
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from end of y5 till adult (~y21)
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Gn-RH
Isoform 15
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CLN3 (438aa)
ENSP00000353116
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as before
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from end of y5 till adult (~y21)
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GH-RH
Isoform 16
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CLN3
CLN6
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as before
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during puberty
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THYM-b10 = Thymosin beta 10
PROG = Progesterone
TPO = Thymopoetin
MET-ENK = Methionine-Encephalin; LEU-ENK= Leucine-Encephalin
All above listed hormones are Formatting-Hormones postulated by the author
(see: Die Formatierte DNA)
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Protein: Palmitoyl-Protein-Thioesterase
16 postulated isoforms in total, all being encoded by the NCL-gene-network.
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Inducing Releasing-
Hormone
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Protein or pre-
cursor(s) coded on gene-loci
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supposed to be expressed during ontogenesis in one or more of the following celltypes or varying combinations of these cells
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Supposed to be expressed from-to (ca.)
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HPL
isoform 1
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CLN3
CLN1
CES7
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(progenitors of) Bipolar-, MĂĽller-, amacrine-, cone-cells, neurons, retinal ganglion cells, muscle cells smooth and striated, oligodendroglia, microglia (Hortega-cells), lymphocytes and specific cells of kidneys, liver and the gastrointestinal tract.
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from day 110
till birth
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HPL
isoform 2
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CLN6
NOMO2
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as before
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from day 160 till day 200
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TRH
isoform 3
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CLN8
USP10
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Bipolar-, MĂĽller-, amacrine-, cone-cells, neurons, retinal ganglion cells, muscle cells smooth and striated, oligodendroglia, microglia (Hortega-cells), lymphocytes and specific cells of kidneys, liver and the gastrointestinal tract.
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from day 200 till birth
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TRH
isoform 4
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CES7
NOMO2
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as before
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from day 200 till begin of adultness
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CRH
isoform 5
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CLN1
NOMO2
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as before
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from birth till
end of y5
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CRH
isoform 6
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CLN1/PPT1
ENSP00000394863
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as before
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from birth till
~year 35
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Gn-RH
isoform 7
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CLN8
CLN3
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as before
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end of y5 till end of puberty
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Gn-RH
isoform 8
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ARSG
USP10
CLN3
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as before
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from birth till begin of adultness
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CRH
isoform 9
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CLN8
CES7
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as before
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end of y5 till
begin of adultness
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Gn-RH
isoform 10
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USP10
FAM117A
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as before
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during puberty
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GH-RH
isoform 11
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CLN8
CLN5
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as before
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during puberty
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GH-RH
isoform 12
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CLN1
CES7
NOMO2
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as before
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from begin of puberty till begin of adultness
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Gn-RH
isoform 13
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CLN5 (407aa)
ENSP00000366673
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as before
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from begin of puberty till begin of adultness
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Gn-RH
isoform 14
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DHRS7
CLN1
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as before
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from begin of puberty till ~y35
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Gn-RH
isoform 15
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CLN1
GPC6
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as before
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from begin of puberty till end of life
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GH-RH
isoform 16
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CLN2
ENSP00000412783
CES7
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as before
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from begin of adultness till end of life
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PROG = Progesterone
MET-ENK = Methionine-Encephalin
LEU-ENK = Leucine-Encephalin
All above listed hormones are Formatting-Hormones postulated by the author
(see: Die Formatierte DNA)
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Protein: acetoin - racemase
12 postulated isoforms in total, all being encoded by the NCL-gene-network.
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Inducing Releasing- Hormone
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Protein or pre-
cursors coded on gene-loci
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supposed to be expressed during ontogenesis in one or more of the following celltypes or varying combinations of these cells
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Supposed to be expressed from-to (ca.)
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PGF2a
Isoform 1
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NOMO2
CES7
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(progenitors of) microglia, astrocyts,oligo- dendroglia, muscle smooth and striated, neurons multipolar (retina) and others.
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day 6 till end of embryogenesis
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HPL
Isoform 2
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CLN3
DHRS7
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as before
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end of embryo-
genesis till
day 110
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PROG
Isoform 3
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NOMO2
USP10
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as before
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from day 110 till day 160
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PROG
Isoform 4
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CTSD
CTSL1
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microglia, astrocyts, oligodendroglia, muscle smooth and striated, neurons multipolar (retina) and others
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from day 160 till day 200
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TRH
Isoform 5
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NOMO2
CES7
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as before
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from day 200 till birth
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CRH
Isoform 6
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USP10
SERPIN B11
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as before
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from birth till
end of y7
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Gn-RH
Isoform 7
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CLN3
CTSF
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as before
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from birth till end of puberty
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MSH-RH
Isoform 8
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CLN8
USP10
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as before
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from birth till reaching adultness
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GH-RH
Isoform 9
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CLN6 (311aa)
ENSP00000249806
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see rel. chapter.
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from birth till
end of life
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GH-RH
Isoform 10
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CLN8 (286aa)
ENSP00000328182
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see rel. chapter.
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begin of puberty till reaching adultness
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Gn-RH
Isoform 11
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CLN3
CLN8
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as before
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begin of puberty till reaching adultness
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MSH-RH
Isoform 12
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CLN3
GPC6
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as before
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begin of puberty till end of life
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PROG = Progesterone
THYM-b10 = Thymosin beta 10
MET-ENK = Methionine-Encephalin
LEU-ENK = Leucine-Encephalin
Ăź-END= beta Endorphine
All above listed hormones are Formatting -Hormones postulated by the author
(see: Die Formatierte DNA)
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Protein: tripeptidyl-peptidase
16 postulated isoforms in total, all being encoded by the NCL-gene-network.
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Inducing Releasing-
Hormone
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Protein or pre-
cursor(s) coded on gene-loci
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supposed to be expressed during ontogenesis in one or more of the following celltypes or varying combinations of these cells
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Supposed to be expressed from-to (ca.)
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ESTRIOL
Isoform 1
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CLN3
CTSF
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(Progenitors of) MĂĽller-, bipolar-, amacrine-, cone cells, fibroblasts, neurons, muscle smooth/striated, oligodendroglia, microglia, astroglia, lymphocytes and oth.
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day 110 till
day 160
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PROG
Isoform 2
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CLN3
CLN6
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as before
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day 160 till
day 200
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CRH
Isoform 3
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CLN3
CTSD
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MĂĽller-, bipolar-, amacrine-, cone cells, fibroblasts, neurons, muscle smooth/ striated, oligodendroglia, microglia, astroglia, lymphocytes and oth.
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day 200
till birth
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CRH
Isoform 4
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DHRS7
SERPINB11
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as before
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birth till begin of puberty
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GH-RH
Isoform 5
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CLN8
USP10
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as before
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birth till begin of puberty
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MSH-RH
Isoform 6
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CLN8
CES7
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as before
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birth till end of puberty
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MSH-RH
Isoform 7
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CLN2 (TPP1)
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as before
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birth till begin
of adultness
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MSH-RH
Isoform 8
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CLN3
CLN6
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as before
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from end of y5 till begin of puberty
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MSH-RH
Isoform 9
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CLN3
CTSD
NOMO2
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as before
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from end of y5 till begin of adultness
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MSH-RH
Isoform 10
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CLN3
DHRS7
CLN6
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as before
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from end of y5 till begin of adultness
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MSH-RH
Isoform 11
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CLN2
ENSP00000398136
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as before
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from end of y5 till begin of adultness
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MSH-RH
Isoform 12
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CLN2
ENSP00000395326
CLN6
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as before
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from end of y5 till ~y40
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MSH-RH
Isoform 13
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CLN2
ENSP00000369169
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as before
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during puberty
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MSH-RH
Isoform 14
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CLN3
CES7
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as before
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during puberty
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MSH-RH
Isoform 15
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CLN6
DHRS7
ARSG
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as before
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from begin of adultness on till end of life
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MET-ENK
Isoform 16
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NOMO2
GPC6
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as before
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from begin of adultness on till end of life
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MET-ENK = Methionine-Encephalin
All above listed hormones are Formatting-Hormones postulated by the author
(see: Die Formatierte DNA)
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Protein: retinol-isomerase
12 postulated isoforms in total, all being encoded by the NCL-gene-network.
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Inducing Releasing-
Hormone
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Protein or pre-
cursor(s) coded on gene-loci
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supposed to be expressed during ontogenesis in one or more of the following celltypes or varying combinations of these cells
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Supposed to be expressed from-to (ca.)
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THYM-b10
Isoform 1
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CLN6
DHRS7
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(progenitors of) Retina Pigment-epithel cells, muscle cells smooth/striated, astroglia, motor-neurons, bipolar nerve-cells, Oligodendroglia, microglia, fibroblasts, lymphoblasts and oth.
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day 100 till
day 160
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TRH
Isoform 2
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CLN3
NOMO2
USP10
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as before
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day 160 till
day 200
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TRH
Isoform 3
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NOMO2
CES7
FAM117A
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Retina Pigment-epithel cells, muscle cells smooth/striated, astroglia, motor-neurons, bipolar nerve-cells, Oligodendroglia, microglia, fibroblasts, lymphoblasts and oth.
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day 200 till
birth
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CRH
Isoform 4
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CLN3
DHRS7
CES7
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as before
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birth till
end of y5
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Gn-RH
Isoform 5
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CLN6
DHRS7
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as before
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birth till
end of y5
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MSH-RH
Isoform 6
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CLN3
USP10
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as before
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birth till
end of y5
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MSH-RH
Isoform 7
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USP10
FAM117A
CLN1
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as before
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end of y5
till begin of
puberty
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MSH-RH
Isoform 8
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CLN3
CES7
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as before
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end of y5 till begin of adultness
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MSH-RH
Isoform 9
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GPC6
CLN6
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as before
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end of y9
till begin of
puberty
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MET-ENK
Isoform 10
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USP10
CES7
FAM117A
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as before
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end of pub.
till ~y30
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MET-ENK
Isoform 11
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CLN6
NOMO2
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as before
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from ~y30
on
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LEU-ENK
Isoform 12
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USP10
NOMO2
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as before
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from ~y30
on
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MET-ENK = Methionine-Encephalin
LEU-ENK = Leucine-Encephalin
All above listed hormones are Formatting-Hormones postulated by the author
(see: Die Formatierte DNA)
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01 All dates listed in tables for expression data are approximate values.
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Protein: cathepsin D
10 postulated isoforms in total, all being encoded by the NCL-gene-network.
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Inducing Releasing-
Hormone
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Protein or pre-
cursor(s) coded on gene-loci
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supposed to be expressed during ontogenesis in one or more of the following celltypes or varying combinations of these cells
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Supposed to be expressed from-to (ca.)
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GH-RH
Isoform 1
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MFSD8
SERPINB11
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(Progenitors of) radialglia, oligodendroglia, microglia, muscle cells smooth/striated, lymphocytes, fibrocytes, distinct cells of kidneys, liver and of the gastro-intestinal system
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day 160 till
birth
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TRH
Isoform 2
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NOMO2
CLN6
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as before
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day 200 till
birth
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GH-RH
Isoform 3
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CTSD
DHRS7
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radialglia, oligodendroglia, mikroglia, muscle cells smooth/striated, lymphocytes, fibrocytes, distinct cells of kidneys, liver and of the gastro-intestinal system
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day 200 till
end of y5
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Gn-RH
Isoform 4
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CTSD
DHRS7
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as before
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day 200 till
end of y5
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GH-RH
Isoform 5
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CTSD
ENSP00000236671
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as before
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birth till
adultness
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Gn-RH
Isoform 6
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CLN6
CLN3
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as before
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birth till
end of life
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Gn-RH
Isoform 7
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CTSD
ENSP00000384947
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as before
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end of y5 till adultness
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MSH-RH
Isoform 8
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FAM117A
NOMO2
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as before
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end of y5 till adultness
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GH-RH
Isoform 9
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CTSD
CES7
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as before
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end of y5 till
end of life
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Gn-RH
Isoform 10
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CLN6
CLN3
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as before
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during puberty
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MET-ENK = Methionine-Encephalin
LEU-ENK = Leucine-Encephalin
All above listed hormones are Formatting-Hormones postulated by the author
(see: Die Formatierte DNA)
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01 All dates listed in tables for expression data are approximate values.
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